Side Effects of Resveratrol

Rats fed large doses of resveratrol showed little or no side effect even to the amount of 1000 mg per kilogram of body weight per day. However, at extremely high doses, reaching 3000 mg per kilogram, more pronounced effects could be observed.

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Extreme doses in rats caused lower body weights and lower food consumption in experiments. In some rats it caused higher than normal bilirubin counts which means that it could contribute to jaundice in humans. Hemoglobin levels were found to be reduced. However, white cell counts were found to be higher. Blood clotting was slightly inhibited and blood was "thinner".

Resveratrol affects the activity of Cytochrome P450. There are over 60 different forms of P450 that deal with different toxins and substances, catalyzing them either for the body's use or to rid them from the system. Because resveratrol may stimulate P450, the body may increase the absorption of some drugs, magnifying their effect. Persons considering taking resveratrol as a supplement should consult a physician if taking prescribed medication.

Another side effect of resveratrol has to do with the body's ability to detoxify itself. Chelation is the process where metals are leached from the body. This can be good (as in the case of lead or mercury poisoning) or bad as in the consumption of essential metals such as iron or copper. Resveratrol can contribute to chelation.

In general, like all good things, resveratrol can be bad in extremely high quantities. However, taken in moderation it does not appear to be harmful for the average human.

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